Our company is dedicated to developing nutritional supplements based on published scientific research.
Shailaja G Raj, MD, FACOG REI:
Dr. Raj is an American Boards Certified Clinician . She currently is in private practice at Southern Fertility Center in Greater New Orleans area and is President of Protegene Corporation, a biotechnology start up dedicated to making “Breast Health guard- Susthana” ( of which she is a Co-discoverer) available as a nutritional supplement. She has conducted many clinical trials.
PC101: Breast Health guard- Susthana.
This is an all natural herbal super cocktail developed based on the research published in Journal of Cancer, vol.4, pages 703-715, November 2013 and Gynecologic Oncology, volume 110, pages 432-438, 2008. 'Susthana' means ‘healthy breast’ in the ancient language of Sanskrit. This is offered as a nutritional supplement for ovary and breast health support and not intended to prevent, diagnose, treat or cure any disease. These statements have not been evaluated by F.D.A. This product is not intented to diagnose, prevent, treat or cure any disease.
Scientific literature cited:
Journal of Cancer, volume 4, pages 703-715, November 2013:
Title of Article: Simultaneous Inhibition of Cell-Cycle, Proliferation, Survival, Metastatic Pathways and Induction of Apoptosis in Breast Cancer Cells by a Phytochemical Super-Cocktail: Genes That Underpin Its Mode of Action
Traditional chemotherapy and radiotherapy for cancer treatment face serious challenges such as drug resistance and toxic side effects. Complementary / Alternative medicine is increasingly being practiced worldwide due to its safety beneficial therapeutic effects. We hypothesized that a super
combination (SC) of known phytochemicals used at bioavailable levels could induce 100% killing of breast cancer (BC) cells without toxic effects on normal cells and that microarray analysis would identify potential genes for targeted therapy of BC. Mesenchymal Stems cells (MSC, control) and two BC cell lines were treated with six well established pro-apoptotic phytochemicals individually and in combination (super cocktail), at bioavailable levels. The compounds were ineffective individually. In combination, they significantly suppressed BC cell proliferation (>80%), inhibited migration and invasion, caused cell cycle arrest and induced apoptosis resulting in 100% cell death. However, there were no deleterious effects on MSC cells used as control. Furthermore, the SC down-regulated the expression of PCNA, Rb, CDK4, BcL-2, SVV, and CD44 (metastasis inducing stem cell factor) in the BC cell lines. Microarray analysis revealed several differentially expressed key genes (PCNA, Rb, CDK4, Bcl-2, SVV, P53 and CD44) underpinning SC-promoted BC cell death and motility. Four unique genes were highly up-regulated (ARC, GADD45B, MYLIP and CDKN1C). This investigation indicates the potential for development of a highly effective phytochemical combination for breast cancer chemoprevention / chemotherapy. The novel over-expressed genes hold the potential for development as markers to follow efficacy of therapy.